000			02217cam a22003738a 4500
001			16780199
005			20100115065456.0
008			110512s2012 nyu b 001 0 eng
010			_a 2011020446
020			_a9781259071409
035			_a(DNLM)101560548
040			_aDNLM/DLC _cDLC
042			_apcc
050	0	0	_aRM301.4 _b.Sh531 2013
100	1		_aShargel, Leon, _d1941-
245	1	0	_aApplied biopharmaceutics & pharmacokinetics / _cLeon Shargel, Andrew B.C. Yu, Susanna Wu-Pong.
246	1		_aApplied biopharmaceutics and pharmacokinetics
250			_a6th ed. _bInternational Edition
260			_aNew York : _bMcGraw-Hill, _c2013.
263			_a2012
300			_axviii, 811 p. ; _c23 cm. _billustrations :
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease.
650		0	_aBiopharmaceutics.
650		0	_aPharmacokinetics.
650	1	2	_aBiopharmaceutics.
650	2	2	_aModels, Chemical.
650	2	2	_aPharmacokinetics.
700	1		_aYu, Andrew B. C., _d1945-
700	1		_aWu-Pong, Susanna.
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2lcc _cBK _kCirc.
955			_bxh11 2011-06-17
999			_c35 _d35