Shargel, Leon,  1941- <br/><br/>
Applied biopharmaceutics & pharmacokinetics / 
 Applied biopharmaceutics and pharmacokinetics 
Leon Shargel, Andrew B.C. Yu, Susanna Wu-Pong. 
 - 6th ed.  International Edition 
 - New York :  McGraw-Hill,  2013. 
 - xviii, 811 p. ;  illustrations :  23 cm. 
<br/><br/>Includes bibliographical references and index. 
<br/><br/>Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease. 
<br/><br/><label>ISBN: </label>9781259071409 
<br/><br/><label>LCCN: </label>2011020446 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Biopharmaceutics.<br/>Pharmacokinetics.<br/>Biopharmaceutics.<br/>Models, Chemical.<br/>Pharmacokinetics.
<br/><br/><label>LC Class. No.: </label>RM301.4  / .Sh531 2013